Original Articles

Bachmann S, Linde J, Bell M, Spehr M, Zempel H, Zimmer-Bensch G (2021). DNA Methyltransferase 1 (DNMT1) Shapes Neuronal Activity of Human iPSC-Derived Glutamatergic Cortical Neurons. International Journal of Molecular Sciences22, 2034.

Pensold D, Gehrmann J, Pitschelatow G, Walberg A, Braunsteffer K, Reichard J, Ravaei A, Linde J, Lampert A, Costa I, Zimmer-Bensch G (2021). The expression of the cancer-associated lncRNA Snhg15 is modulated by ephrinA5-induced signaling. International Journal of Molecular Sciences, 22(3): 1332

Bayer C, Pitschelatow G, Hannemann N, Linde J, Reichard J, Pensold D, Zimmer-Bensch G (). The DNA methyltransferase 1 (DNMT1) acts on neurodegeneration by modulating proteostasis-relevant intracellular processes. 21(15): 5420

Hahn A, Bayer C, Pensold D, Tittelmeier J, Marx-Blümel L, González-Bermúdez L, Linde J, Groß J, Salinas-Riester G, Lingner T, von Maltzahn J, Spehr M, Pieler T, Urbach A, Zimmer-Bensch G (2020). DNA methyltransferase 1 (DNMT1) function is implicated in the age-related loss of cortical interneurons. Frontiers in Cell and Developmental Biology, 8: 639

Symmank J, Bayer C, Reichard J, Pensold D, & Zimmer-Bensch G (2020). Neuronal Lhx1 expression is regulated by DNMT1-dependent modulation of histone marks. Epigenetics, 1-16

Pensold D, Reichard J, Van Loo KMJ, Ciganok N, Hahn A, Bayer C, Liebmann L, Groß J, Tittelmeier J, Lingner T, Salinas-Riester G, Symmank J, Halfmann C, González-Bermúdez L, Urbach A, Gehrmann J, Costa I, Pieler T, Hübner C, Vatter H, Kampa B, Becker AJ and Zimmer-Bensch G (2020). DNA methylation-mediated modulation of endocytosis as potential mechanism for synaptic function regulation in murine inhibitory cortical interneurons. Cerebral Cortex, 30(7): 3921–3937

Symmank J, Gölling V, Gerstmann K and Zimmer G (2019). The Transcription Factor LHX1 Regulates the Survival and Directed Migration of POA-derived Cortical Interneurons. Cerebral Cortex, 29(4): 1644-1658

Symmank J, Bayer C, Schmidt C, Hahn A, Pensold D and Zimmer-Bensch G (2018). DNMT1 modulates interneuron morphology by regulating Pak6 expression through crosstalk with histone modifications. Epigenetics, 13(5): 536-556

Pensold D, Symmank J, Hahn A, Lingner T, Salinas-Riester G, Downie B, Ludewig F, Rotzsch A, Haag N, Andreas N, Schubert K, Hübner C, Pieler T, Zimmer G (2017). The DNA Methyltransferase 1 (DNMT1) Controls the Shape and Dynamics of Migrating POA- Derived Interneurons Fated for the Murine Cerebral Cortex. Cerebral Cortex, 27(12): 5696-5714

Gerstmann K, Pensold D, Symmank J, Khundadze M, Hübner C, Bolz J, Zimmer G (2015). Thalamic afferents influence cortical progenitors via ephrinA5/EphA4 interactions. Development, 142:140-150

Rudolph J, Gerstmann K, Zimmer G, Steinecke A, Döding A, Bolz J (2014). A dual role of EphB1/ephrinB3 reverse signaling on migrating striatal and cortical neurons originating in the preoptic area: should I stay or go away? Front Cell Neurosc, 8: 185

Steinecke A, Gampe C, Zimmer G, Rudolph J, Bolz J (2014). EphA/ephrin-A reverse signaling promotes the migration of MGE-derived cortical interneurons. Development, 141: 460-471

Beetz C, Koch N, Khundadze M, Zimmer G, Nietzsche S, Hertel N, Huebner A, Mumtaz R, Schweizer M, Dirren E, Karle E, Irintchev A, Alvarez V, Redies C, Westermann M, Kurth I, Deufel T, Kessels M, Qualmann B, Hübner C (2014). A spastic paraplegia mouse model reveals REEP1-dependent ER shaping. J Clin Invest, 124(6): 2809

Khundadze M, Kollmann K, Koch N, Biskup C, Nietzsche S, Zimmer G, Hennings C, Huebner A, Symmank J, Jahic A, Ilina E, Karle K, Schöls L, Kessels M, Braulke T, Qualmann B, Kurth I, Beetz C, Hübner C (2013). A hereditary spastic paraplegia mouse model reveals an essential role of ZFYVE26 for the endolysosomal system. PLoS Genet, 9(12)

Rüdiger T, Zimmer G, Bachmann S, Castellini V, Bagnard D and Bolz J (2012). Integration of opposing semaphoring guidance cues in cortical axons. Cereb Cortex, 23(3): 604-14

Zimmer G, Rudolph J, Landmann J, Gerstmann K, Steinecke A, Gampe C, Bolz J (2011). Bidirectional ephrinB3/EphA4 signaling mediates the segregation of MGE-and POA derived interneurons in the deep and superficial migratory stream. J Neurosci 31(50): 18364-18380.

Rudolph J, Zimmer G, Steinecke A, Barchmann S, Bolz J (2010). Ephrins guide migrating cortical interneurons in the basal telencephalon. Cell Adh Migr, 4(3): 400-408

Zimmer G, Schanuel SM, Burger S, Weth F, Steinecke A, Bolz J, Lent R (2010). Chondroitin sulfate acts in concert with semaphorin 3A to guide tangential migration of cortical interneurons in the ventral telencephalon. Cereb Cortex, 20(10): 2411-2422

Zimmer G, Garcez P, Rudolph J, Niehage R, Weth F, Lent R, Bolz J (2008). Ephrin-A5 acts as a repulsive cue for migrating cortical interneurons. Eur J Neurosci, 28(1): 62-73

Zimmer G, Kastner B, Weth F, Bolz J (2007). Multiple effects of ephrin-A5 on cortical neurons are mediated by SRC family kinases. J Neurosci, 27(21): 5643-5653


Ravaei, A., Zimmer-Bensch, G., Govoni, M., & Rubini, M. (2022). lncRNA-mediated synovitis in Rheumatoid arthritis: A perspective for biomarker developmentProgress in Biophysics and Molecular Biology.

Jakovcevski, M., & Zimmer-Bensch, G. (2021). Epigenetic function in neurodevelopment and cognitive impairment. Neuroforum.

Zimmer-Bensch G, Zempel H (2021). DNA Methylation in Genetic and Sporadic Forms of Neurodegeneration: Lessons from Alzheimer’s, Related Tauopathies and Genetic Tauopathies. Cells, 10, 3064.

Reichard J, Zimmer-Bensch G (2021). The Epigenome in Neurodevelopmental Disorders. Frontiers in Neuroscience

Pensold D, Zimmer-Bensch G (2021). DNMT1-dependent regulation of cortical interneuron function and survival. Neural Regeneration Research

Javier-Torrent M, Zimmer-Bensch G, Nguyen L (2020). Mechanical Forces Orchestrate Brain Development. Trends in Neurosciences

Linde J, Zimmer-Bensch G (2020). DNA methylation-dependent dysregulation of GABAergic interneuron functionality in neuropsychiatric diseases. Frontiers in Neuroscience

Zimmer-Bensch G (2020). Epigenomic Remodeling in Huntington’s Disease—Master or Servant? Epigenomes, 4(3): 15

Zimmer-Bensch G (2019). Emerging Roles of Long Non-Coding RNAs as Drivers of Brain Evolution. Cells, 8(11): E1399

Symmank J, Zimmer-Bensch G (2019). LHX1-a multifunctional regulator in preoptic area-derived interneuron development. Neural Regen Res, 14(7): 1213-1214

Zimmer-Bensch G (2018). Diverse facets of cortical interneuron migration regulation-Implications of neuronal activity and epigenetics. Brain Research, 1700: 160-169

Pensold D, Zimmer G (2018). Single cell transcriptomics reveals regulators of neuronal migration and maturation during brain development. Journal of Experimental Neuroscience, 12: 1179069518760783

Gerstmann K, Zimmer G (2018). The role of the Eph/ephrin family during cortical development and cerebral malformations. Medical Research Archives, 6(3)

Symmank J, Zimmer G (2017). Regulation of neuronal survival by DNA-Methyltransferases. Neural Regen Res, 12(11): 1768-1775.

Gerstmann K and Zimmer G (2015). Fine-tuning of cortical progenitor proliferation by thalamic afferents. Neural Regen Res, 10(6):887-8

Book chapters

Yildiz, C.B., Zimmer-Bensch, G. (2022). Role of DNMTs in the Brain. In: Jeltsch, A., Jurkowska, R.Z. (eds) DNA Methyltransferases – Role and Function. Advances in Experimental Medicine and Biology, vol 1389. Springer, Cham.

Pensold D, Zimmer-Bensch G (2020) Methods for Single-Cell Isolation and Preparation (Book Chapter in:  Single-cell Sequencing and Methylation. Advances in Experimental Medicine and Biology), Volume 1255, Editors: Yu B., Zhang J., Zeng Y., Li L., Wang X.; Springer, Singapore.

Zimmer-Bensch G (2019). Functional implications of dynamic DNA methylation for the developing, aging and diseased brain (Book Chapter in The DNA, RNA, and Histone Methylomes), Volume 9, Editors: Jurga S. and Barciszewski J.; Springer