Profile of the department:
We focus on epigenetic gene regulation that instructs discrete neurophysiological processes underlying brain development and adult neuronal function in disease-related contexts. Epigenetic control emerges as a highly dynamic process on top of transcriptional networks governing diverse biological functions in neurodevelopment, aging and disease. We aim to decipher cell type-, stage- and context-specific epigenetic profiles, to approach disease- and age-related questions, with the ultimate goal to open new avenues for the establishment of epigenetic-based therapies. To this end, we apply highly innovative techniques such as sequencing-based single cell and global transcriptome analysis, as well as global and site-specific methylation analysis in addition to chromatin-immunoprecipitation. We work with transgenic mouse models in addition to cell and primary cultures. We are specialized in diverse in vivo and in vitro transfection techniques, and make use of sophisticated microscopic systems including Life Cell Imaging.

If interested and wishing more detailed information, please don’t hesitate to contact:

Prof. Geraldine Zimmer-Bensch
zimmer@bio2.rwth-aachen.de